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He, Chuan

One or more keywords matched the following properties of He, Chuan

Property	Value
keywords	DNA methylation
overview	Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.

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Value

keywords

DNA methylation

overview

Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.

One or more keywords matched the following items that are connected to He, Chuan

Item Type	Name
Concept	Adenine
Concept	Acetylation
Concept	Adenosine
Concept	Adenosine Diphosphate
Concept	Anticodon
Concept	Aged, 80 and over
Concept	Alkylation
Concept	Azides
Concept	Adolescent
Concept	Aged
Concept	alpha 1-Antitrypsin
Concept	Amination
Concept	Amino Acid Sequence
Concept	Adult
Concept	Anisoles
Concept	Antibodies, Anti-Idiotypic
Concept	Antibodies, Monoclonal
Concept	B-Lymphocytes
Concept	Base Sequence
Concept	Celiac Disease
Concept	Dealkylation
Concept	Benzopyrans
Concept	DNA Damage
Concept	Azacitidine
Concept	Bacterial Outer Membrane Proteins
Concept	Pan troglodytes
Concept	Chlamydomonas
Concept	Biophysics
Concept	Carbon Monoxide
Concept	Child
Concept	Fertility
Concept	Cell Transformation, Neoplastic
Concept	Chlorophyll
Concept	Glutathione Peroxidase
Concept	Guinea Pigs
Concept	Cricetulus
Concept	Hydroxylation
Concept	DNA Transposable Elements
Concept	DNA-Binding Proteins
Concept	DNA, Mitochondrial
Concept	Immunosuppressive Agents
Concept	Insulin
Concept	Cytidine
Concept	DNA Repair
Concept	DNA, Bacterial
Concept	Child, Preschool
Concept	Mammary Neoplasms, Experimental
Concept	DNA
Concept	Drosophila melanogaster
Concept	Fragile X Syndrome
Concept	Ferrous Compounds
Concept	Infant, Newborn
Concept	Methyltransferases
Concept	Fluorescence
Concept	Deamination
Concept	Deoxyadenosines
Concept	Glioma
Concept	Glycosylation
Concept	Ferric Compounds
Concept	DNA (Cytosine-5-)-Methyltransferases
Concept	Obesity
Concept	Oncogenes
Concept	Hydrogen Peroxide
Concept	Liver Neoplasms
Concept	Immunoglobulin Heavy Chains
Concept	Peptide Chain Initiation, Translational
Concept	Escherichia coli
Concept	Fluorometry
Concept	Infant
Concept	Fourier Analysis
Concept	Light
Concept	Carcinoma, Hepatocellular
Concept	Monoclonal Gammopathy of Undetermined Significance
Concept	Macaca mulatta
Concept	Mammals
Concept	Naphthoquinones
Concept	Neodymium
Concept	Mice, Transgenic
Concept	Organ Culture Techniques
Concept	Organ Size
Concept	Molecular Sequence Data
Concept	Oxidoreductases, N-Demethylating
Concept	Mice, Inbred BALB C
Concept	Mice, Inbred C57BL
Concept	Mice, Nude
Concept	Middle Aged
Concept	Myelodysplastic Syndromes
Concept	Cricetinae
Concept	Pentoxyl
Concept	RNA Precursors
Concept	RNA, Ribosomal, 28S
Concept	Nerve Growth Factors
Concept	Nitric Oxide
Concept	Neurons
Concept	Nucleosomes
Concept	Nucleotides
Concept	Oogenesis
Concept	Organic Chemicals
Concept	Ovarian Neoplasms
Concept	Oxidation-Reduction
Concept	Liver
Concept	Salicylates
Concept	Oocytes
Concept	Organophosphorus Compounds
Concept	Penicillium
Concept	Endopeptidases
Concept	Photochemistry
Concept	Poly A
Concept	Phosphoprotein Phosphatases
Concept	Phosphorylation
Concept	Polyglutamic Acid
Concept	Operon
Concept	Organoids
Concept	Oxygen
Concept	Protein-Tyrosine Kinases
Concept	Protein Processing, Post-Translational
Concept	Proto-Oncogene Proteins
Concept	Genetic Markers
Concept	Mixed Function Oxygenases
Concept	Guanine
Concept	Guanosine
Concept	RNA, Neoplasm
Concept	Protein Kinases
Concept	Pseudouridine
Concept	S-Adenosylmethionine
Concept	Siloxanes
Concept	Regulatory Sequences, Nucleic Acid
Concept	Ribonucleoproteins
Concept	Spectrum Analysis
Concept	Salmonella typhimurium
Concept	Spermatogenesis
Concept	RNA Polymerase II
Concept	DNA-Directed RNA Polymerases
Concept	Swine
Concept	Heparin
Concept	Histones
Concept	Humans
Concept	Linear Models
Concept	Protein Biosynthesis
Concept	Tretinoin
Concept	Software
Concept	Thermodynamics
Concept	Oxidants
Concept	Tumor Necrosis Factor-alpha
Concept	Caenorhabditis elegans
Concept	Spectroscopy, Fourier Transform Infrared
Concept	Protein Engineering
Concept	Oxo-Acid-Lyases
Concept	Ultraviolet Rays
Concept	Oligonucleotide Probes
Concept	Organelles
Concept	Zygote
Concept	Site-Specific DNA-Methyltransferase (Adenine-Specific)
Concept	Biosensing Techniques
Concept	DNA Adducts
Concept	Drug Resistance, Neoplasm
Concept	Radiopharmaceuticals
Concept	Reverse Transcriptase Polymerase Chain Reaction
Concept	RNA Splice Sites
Concept	NF-kappa B
Concept	HMGA2 Protein
Concept	Up-Regulation
Concept	RNA, Nuclear
Concept	Neoplasms, Second Primary
Concept	Chlamydomonas reinhardtii
Concept	Mitochondria
Concept	Multiple Myeloma
Concept	DNA Probes
Concept	Interleukin-7
Concept	Proto-Oncogene Proteins c-myc
Concept	Mutagenesis, Site-Directed
Concept	Sequence Analysis, DNA
Concept	Protein Structure, Tertiary
Concept	Melanoma
Concept	Methylation
Concept	Myelin Sheath
Concept	Neoplasm Metastasis
Concept	Neoplasm Recurrence, Local
Concept	Nickel
Concept	Oligodendroglia
Concept	RNA-Binding Proteins
Concept	Mice, Knockout
Concept	Oxidative Stress
Concept	beta-Lactam Resistance
Concept	Wnt1 Protein
Concept	Fragile X Mental Retardation Protein
Concept	Mutation, Missense
Concept	Norfloxacin
Concept	Nucleic Acid Denaturation
Concept	Reactive Oxygen Species
Concept	Protein Structure, Secondary
Concept	Drug Resistance, Bacterial
Concept	Karyopherins
Concept	Receptors, G-Protein-Coupled
Concept	DNA Repair Enzymes
Concept	Periplasmic Binding Proteins
Concept	beta-Lactams
Concept	Embryonic Development
Concept	DNA, Algal
Concept	Histone Code
Concept	Thymine DNA Glycosylase
Concept	Hepatocyte Nuclear Factor 3-alpha
Concept	Chromatin Immunoprecipitation
Concept	Amino Acid Substitution
Concept	DNA Footprinting
Concept	RNA Helicases
Concept	Oligonucleotide Array Sequence Analysis
Concept	Amino Acid Motifs
Concept	Base Pairing
Concept	Salicylic Acid
Concept	Periodicals as Topic
Concept	Phosphoric Monoester Hydrolases
Concept	Organophosphates
Concept	Platinum
Concept	Plasmodium
Concept	Promoter Regions, Genetic
Concept	Pseudomonas aeruginosa
Concept	Mice
Concept	Protein Kinase C
Concept	Metal Nanoparticles
Concept	HIV Reverse Transcriptase
Concept	tRNA Methyltransferases
Concept	Saccharomyces cerevisiae
Concept	Ribose
Concept	Spectrometry, Fluorescence
Concept	Structure-Activity Relationship
Concept	Biomedical Research
Concept	Ralstonia
Concept	Dioxygenases
Concept	ARNTL Transcription Factors
Concept	Antibodies, Monoclonal, Humanized
Concept	Immunoprecipitation
Concept	Trypsin
Concept	Uracil
Concept	Uridine
Concept	Stereoisomerism
Concept	Vancomycin
Concept	Insulin-Secreting Cells
Concept	Temperature
Concept	Immunoblotting
Concept	Blotting, Western
Concept	Down-Regulation
Concept	CDC2 Protein Kinase
Concept	Molecular Imaging
Concept	Benzothiazoles
Concept	Reproducibility of Results
Concept	Minor Histocompatibility Antigens
Concept	Polymerase Chain Reaction
Concept	Lymphoma, Large B-Cell, Diffuse
Concept	Arabidopsis
Concept	DNA Methylation
Concept	Salmonella enterica
Concept	Spectrometry, Mass, Electrospray Ionization
Concept	Xenograft Model Antitumor Assays
Concept	Microscopy, Atomic Force
Concept	Cell Lineage
Concept	Metagenomics
Concept	Metallochaperones
Concept	O(6)-Methylguanine-DNA Methyltransferase
Concept	Heterogeneous-Nuclear Ribonucleoprotein K
Concept	Seedlings
Concept	Pseudomonas syringae
Concept	Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)
Concept	Extracellular Signal-Regulated MAP Kinases
Concept	p300-CBP Transcription Factors
Concept	Janus Kinase 2
Concept	Genome-Wide Association Study
Concept	Cryptochromes
Concept	Endoplasmic Reticulum-Associated Degradation
Concept	Heterogeneous-Nuclear Ribonucleoproteins
Concept	Heterogeneous-Nuclear Ribonucleoprotein Group C
Concept	RNA, Small Interfering
Concept	Nanotechnology
Concept	Molecular Sequence Annotation
Concept	Mutation Rate
Concept	Intracellular Signaling Peptides and Proteins
Concept	Meiotic Prophase I
Concept	Suppressor of Cytokine Signaling Proteins
Concept	Myeloid-Lymphoid Leukemia Protein
Concept	fms-Like Tyrosine Kinase 3
Concept	Pore Forming Cytotoxic Proteins
Concept	Kaplan-Meier Estimate
Concept	Drug Discovery
Concept	Epigenomics
Concept	Nanopores
Concept	Diet, High-Fat
Concept	Alzheimer Disease
Concept	Amides
Concept	Antibodies
Concept	Biochemistry
Concept	Brain Neoplasms
Concept	Chromatin
Concept	Cyclization
Concept	Cytosine
Concept	Deoxycytidine
Concept	DNA Helicases
Concept	DNA, Single-Stranded
Concept	Doxorubicin
Concept	Drug Resistance, Microbial
Concept	Enhancer Elements, Genetic
Concept	Immunoglobulin Light Chains
Concept	Indenes
Concept	Learning
Concept	Neuroblastoma
Concept	Oligonucleotides
Concept	Organ Specificity
Concept	Peptides
Concept	Peptidoglycan
Concept	Phenotype
Concept	Phylogeny
Concept	Prospective Studies
Concept	Histone-Lysine N-Methyltransferase
Concept	RNA, Ribosomal
Concept	RNA, Ribosomal, 18S
Concept	RNA, Small Nuclear
Concept	Staining and Labeling
Concept	Sulfenic Acids
Concept	T-Lymphocytes
Concept	Thymine
Concept	DNA-Cytosine Methylases
Concept	Cytokines
Concept	Mice, SCID
Concept	Mice, Inbred NOD
Concept	Computational Biology
Concept	Myeloid Cells
Concept	Genomics
Concept	Databases, Nucleic Acid
Concept	Fluorescence Resonance Energy Transfer
Concept	MicroRNAs
Concept	Protein Array Analysis
Concept	Cyclin-Dependent Kinase 9
Concept	5-Methylcytosine
Concept	Organogold Compounds
Concept	Proto-Oncogene Proteins c-akt
Concept	Transcription Factor CHOP
Concept	Lymphoid Enhancer-Binding Factor 1
Concept	Ubiquitination
Concept	Neurogenesis
Concept	SOXE Transcription Factors
Concept	Young Adult
Concept	Coordination Complexes
Concept	Nucleotide Motifs
Academic Article	Spectroscopic insights into lead(II) coordination by the selective lead(II)-binding protein PbrR691.
Academic Article	Capsule anchoring in Bacillus anthracis occurs by a transpeptidation reaction that is inhibited by capsidin.
Academic Article	Genome-wide analysis of N1-methyl-adenosine modification in human tRNAs.
Academic Article	The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA.
Academic Article	Syntheses of two 5-hydroxymethyl-2'-deoxycytidine phosphoramidites with TBDMS as the 5-hydroxymethyl protecting group and their incorporation into DNA.
Academic Article	Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine.
Academic Article	Isopeptide bonds of the major pilin protein BcpA influence pilus structure and bundle formation on the surface of Bacillus cereus.
Academic Article	Structural and biochemical characterization of N5-carboxyaminoimidazole ribonucleotide synthetase and N5-carboxyaminoimidazole ribonucleotide mutase from Staphylococcus aureus.
Academic Article	The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis.
Academic Article	The structure of the human AGT protein bound to DNA and its implications for damage detection.
Academic Article	A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus.
Academic Article	Crystal structures of the reduced, sulfenic acid, and mixed disulfide forms of SarZ, a redox active global regulator in Staphylococcus aureus.
Academic Article	Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus.
Academic Article	Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Academic Article	Synthesis of photoactive analogues of a cystine knot trypsin inhibitor protein.
Academic Article	N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.
Academic Article	An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus.
Academic Article	Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA.
Academic Article	Selective fluorescent probes for live-cell monitoring of sulphide.
Academic Article	FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA.
Academic Article	HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.
Academic Article	TET1 plays an essential oncogenic role in MLL-rearranged leukemia.
Academic Article	Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.
Academic Article	Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.
Academic Article	Unique features of the m6A methylome in Arabidopsis thaliana.
Academic Article	A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Academic Article	N6-methyladenosine-dependent regulation of messenger RNA stability.
Academic Article	Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming.
Academic Article	ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Academic Article	Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.
Academic Article	Gene expression regulation mediated through reversible m6A RNA methylation.
Academic Article	Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA.
Academic Article	The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism.
Academic Article	Preparation of DNA containing 5-hydroxymethyl-2'-deoxycytidine modification through phosphoramidites with TBDMS as 5-hydroxymethyl protecting group.
Academic Article	Preparation and characterization of the native iron(II)-containing DNA repair AlkB protein directly from Escherichia coli.
Academic Article	Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae.
Academic Article	Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases.
Academic Article	A new 1'-methylenedisulfide deoxyribose that forms an efficient cross-link to DNA cytosine-5 methyltransferase (DNMT).
Academic Article	Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing.
Academic Article	An exceptionally selective lead(II)-regulatory protein from Ralstonia metallidurans: development of a fluorescent lead(II) probe.
Academic Article	Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Academic Article	Grand challenge commentary: RNA epigenetics?
Academic Article	Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria.
Academic Article	Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.
Academic Article	A diazirine-based nucleoside analogue for efficient DNA interstrand photocross-linking.
Academic Article	Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine.
Academic Article	Direct functionalization of arenes by primary alcohol sulfonate esters catalyzed by gold(III).
Academic Article	AirSR, a [2Fe-2S] cluster-containing two-component system, mediates global oxygen sensing and redox signaling in Staphylococcus aureus.
Academic Article	Potential functional roles of DNA demethylation intermediates.
Academic Article	Dynamic RNA modifications in posttranscriptional regulation.
Academic Article	Staphylococcus aureus CymR is a new thiol-based oxidation-sensing regulator of stress resistance and oxidative response.
Academic Article	Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
Academic Article	Nonenzymatic labeling of 5-hydroxymethylcytosine in nanopore sequencing.
Academic Article	Engineering a uranyl-specific binding protein from NikR.
Academic Article	Detection of mismatched 5-hydroxymethyluracil in DNA by selective chemical labeling.
Academic Article	Aureusimines in Staphylococcus aureus are not involved in virulence.
Academic Article	Gold(I)-catalyzed intermolecular addition of phenols and carboxylic acids to olefins.
Academic Article	Using the bias from flow to elucidate single DNA repair protein sliding and interactions with DNA.
Academic Article	Design of an emission ratiometric biosensor from MerR family proteins: a sensitive and selective sensor for Hg2+.
Academic Article	N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas.
Academic Article	The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression.
Academic Article	Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics.
Academic Article	The tightly regulated copper window in yeast.
Academic Article	TET family proteins: oxidation activity, interacting molecules, and functions in diseases.
Academic Article	Chemical methods to study protein-nucleic acid interactions.
Academic Article	Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA.
Academic Article	Platinum(II)-catalyzed intramolecular cyclization of o-substituted aryl alkynes through sp3 C-H activation.
Academic Article	How do DNA repair proteins locate potential base lesions? a chemical crosslinking method to investigate O6-alkylguanine-DNA alkyltransferases.
Academic Article	Crystal structures of SlyA protein, a master virulence regulator of Salmonella, in free and DNA-bound states.
Academic Article	Intramolecular additions of alcohols and carboxylic acids to inert olefins catalyzed by silver(I) triflate.
Academic Article	Probing the structure and function of the Escherichia coli DNA alkylation repair AlkB protein through chemical cross-linking.
Academic Article	Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins.
Academic Article	A non-heme iron-mediated chemical demethylation in DNA and RNA.
Academic Article	Diazirine-based DNA photo-cross-linking probes for the study of protein-DNA interactions.
Academic Article	Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins.
Academic Article	Cancer: Damage prevention targeted.
Academic Article	Bioorthogonal labeling of 5-hydroxymethylcytosine in genomic DNA and diazirine-based DNA photo-cross-linking probes.
Academic Article	A general strategy to convert the MerR family proteins into highly sensitive and selective fluorescent biosensors for metal ions.
Academic Article	Nucleic acid modifications with epigenetic significance.
Academic Article	Mapping recently identified nucleotide variants in the genome and transcriptome.
Academic Article	Selective recognition of metal ions by metalloregulatory proteins.
Academic Article	Efficient aziridination of olefins catalyzed by a unique disilver(I) compound.
Academic Article	Detection of 5-hydroxymethylcytosine in DNA by transferring a keto-glucose by using T4 phage ß-glucosyltransferase.
Academic Article	Direct reversal of DNA alkylation damage.
Academic Article	Efficient functionalization of aromatic C-H bonds catalyzed by gold(III) under mild and solvent-free conditions.
Academic Article	Reversible RNA adenosine methylation in biological regulation.
Academic Article	Syntheses of 5-formyl- and 5-carboxyl-dC containing DNA oligos as potential oxidation products of 5-hydroxymethylcytosine in DNA.
Academic Article	Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection.
Academic Article	Nucleic acid oxidation in DNA damage repair and epigenetics.
Academic Article	Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2.
Academic Article	Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa.
Academic Article	In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS.
Academic Article	Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.
Academic Article	Gold-catalyzed organic transformations.
Academic Article	Reading RNA methylation codes through methyl-specific binding proteins.
Academic Article	Synthesis of a FTO inhibitor with anticonvulsant activity.
Academic Article	Dynamic copper(I) imaging in mammalian cells with a genetically encoded fluorescent copper(I) sensor.
Academic Article	Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine.
Academic Article	Modeling non-heme iron proteins.
Academic Article	Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system.
Academic Article	Gold(I)-catalyzed formation of 3-pyrazolines through cycloaddition of diaziridine to alkynes.
Academic Article	Brønsted acid catalyzed addition of phenols, carboxylic acids, and tosylamides to simple olefins.
Academic Article	Nitrene transfer reactions catalyzed by gold complexes.
Academic Article	Gold(III)-catalyzed nitrene insertion into aromatic and benzylic C-H groups.
Academic Article	Detection of 5-hydroxymethylcytosine in a combined glycosylation restriction analysis (CGRA) using restriction enzyme Taq(a)I.
Academic Article	Gold(I)-catalyzed intra- and intermolecular hydroamination of unactivated olefins.
Academic Article	Live Cell MicroRNA Imaging Using Cascade Hybridization Reaction.
Academic Article	RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation.
Academic Article	Decoding the transcriptome and DNA methylome of human primordial germ cells.
Academic Article	High-Resolution Mapping of N6-Methyladenosine in Transcriptome and Genome Using a Photo-Crosslinking-Assisted Strategy.
Academic Article	Preparation of Human Nuclear RNA m6A Methyltransferases and Demethylases and Biochemical Characterization of Their Catalytic Activity.
Academic Article	Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation.
Academic Article	DNA N(6)-methyladenine: a new epigenetic mark in eukaryotes?
Academic Article	Base-resolution detection of N4-methylcytosine in genomic DNA using 4mC-Tet-assisted-bisulfite- sequencing.
Academic Article	Detecting hepatocellular carcinoma in blood.
Academic Article	RNA epigenetics--chemical messages for posttranscriptional gene regulation.
Academic Article	Weakened N3 Hydrogen Bonding by 5-Formylcytosine and 5-Carboxylcytosine Reduces Their Base-Pairing Stability.
Academic Article	The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA.
Academic Article	Nucleic Acid Modifications in Regulation of Gene Expression.
Academic Article	Identification of MLL-fusion/MYC?miR-26?TET1 signaling circuit in MLL-rearranged leukemia.
Academic Article	Characterization of eukaryotic DNA N(6)-methyladenine by a highly sensitive restriction enzyme-assisted sequencing.
Academic Article	A glance at N(6)-methyladenosine in transcript isoforms.
Academic Article	A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
Academic Article	Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.
Academic Article	ALKBH1-Mediated tRNA Demethylation Regulates Translation.
Academic Article	Synthesis of DNA oligos containing 2'-deoxy-2'-fluoro-D-arabinofuranosyl-5-carboxylcytosine as hTDG inhibitor.
Academic Article	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.
Academic Article	Developing drugs targeting transition metal homeostasis.
Academic Article	Chromate Binding and Removal by the Molybdate-Binding Protein ModA.
Academic Article	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision.
Academic Article	DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?
Academic Article	Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.
Academic Article	RNA modifications modulate gene expression during development.
Academic Article	Epigenetics: Making your mark on DNA.
Academic Article	m6A facilitates hippocampus-dependent learning and memory through YTHDF1.
Academic Article	FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function.
Academic Article	Making Changes: N6-Methyladenosine-Mediated Decay Drives the Endothelial-to-Hematopoietic Transition.
Academic Article	RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.
Academic Article	m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Academic Article	Single base resolution mapping of 2'-O-methylation sites in human mRNA and in 3' terminal ends of small RNAs.
Academic Article	Author Correction: RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.
Academic Article	"Gamete On" for m6A: YTHDF2 Exerts Essential Functions in Female Fertility.
Academic Article	Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Academic Article	Kinetic gating mechanism of DNA damage recognition by Rad4/XPC.
Academic Article	High-Resolution Mapping of N 6-Methyladenosine Using m6A Crosslinking Immunoprecipitation Sequencing (m6A-CLIP-Seq).
Grant	Regulation of IL-6 and DNA and RNA methylation by PM-induced mitochondrial ROS
Grant	Mechanisms of Pancreatic Cancer Inhibition by SPARC
Grant	Mechanism of SPARC peptide FSEC inhibition of angiogenesis in neuroblastoma
Academic Article	Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis.
Academic Article	Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis.
Academic Article	Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA.
Academic Article	METTL14 is essential for ß-cell survival and insulin secretion.
Academic Article	Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers.
Academic Article	Jump-seq: Genome-Wide Capture and Amplification of 5-Hydroxymethylcytosine Sites.
Academic Article	5-Hydroxymethylcytosine Profiles Are Prognostic of Outcome in Neuroblastoma and Reveal Transcriptional Networks That Correlate With Tumor Phenotype.
Academic Article	m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Academic Article	Detailed modeling of positive selection improves detection of cancer driver genes.
Academic Article	Prognostic implications of 5-hydroxymethylcytosines from circulating cell-free DNA in diffuse large B-cell lymphoma.
Academic Article	5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.
Academic Article	m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination.
Academic Article	N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription.
Academic Article	DNA 5-Methylcytosine-Specific Amplification and Sequencing.
Academic Article	N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Academic Article	Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ.
Academic Article	YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators.
Academic Article	REPIC: a database for exploring the N6-methyladenosine methylome.
Academic Article	Author Correction: Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ.
Academic Article	Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation.
Academic Article	A New Model of Spontaneous Colitis in Mice Induced by Deletion of an RNA m6A Methyltransferase Component METTL14 in T Cells.
Academic Article	Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution.
Academic Article	LEAD-m6 A-seq for Locus-Specific Detection of N6 -Methyladenosine and Quantification of Differential Methylation.
Academic Article	Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation.
Academic Article	N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.
Academic Article	A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation.
Academic Article	m6 A RNA methylation: from mechanisms to therapeutic potential.
Academic Article	Alterations of 5-hydroxymethylation in circulating cell-free DNA reflect molecular distinctions of subtypes of non-Hodgkin lymphoma.
Academic Article	Chromatin and transcriptional regulation by reversible RNA methylation.
Academic Article	N6 -methyladenosine modification of lncRNA Pvt1 governs epidermal stemness.
Academic Article	Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Academic Article	ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing.
Academic Article	Wnt signaling pathway involvement in genotypic and phenotypic variations in Waardenburg syndrome type 2 with MITF mutations.
Academic Article	METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
Academic Article	HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease.
Academic Article	KAS-seq: genome-wide sequencing of single-stranded DNA by N3-kethoxal-assisted labeling.
Academic Article	The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation.
Academic Article	Utility of Perioperative Measurement of Cell-Free DNA and Circulating Tumor DNA in Informing the Prognosis of GI Cancers: A Systematic Review.
Academic Article	FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development.
Academic Article	Development of Mild Chemical Catalysis Conditions for m1A-to-m6A Rearrangement on RNA.
Academic Article	spKAS-seq reveals R-loop dynamics using low-input materials by detecting single-stranded DNA with strand specificity.
Academic Article	Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma.
Academic Article	N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell survival to maintain normal colonic epithelial morphogenesis.
Academic Article	Exon architecture controls mRNA m6A suppression and gene expression.
Academic Article	m6A-SAC-seq for quantitative whole transcriptome m6A profiling.
Academic Article	Mammalian DNA N6-methyladenosine: Challenges and new insights.
Concept	RNA Recognition Motif Proteins
Concept	Serine-Arginine Splicing Factors
Concept	Suppressor of Cytokine Signaling 1 Protein
Concept	Sequestosome-1 Protein
Concept	AlkB Homolog 1, Histone H2a Dioxygenase
Concept	AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
Concept	AlkB Homolog 5, RNA Demethylase
Concept	AlkB Homolog 8, tRNA Methyltransferase
Concept	Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Concept	PAX3 Transcription Factor
Concept	RNA Splicing Factors
Concept	AlkB Enzymes
Concept	AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
Concept	Myeloid-Derived Suppressor Cells
Concept	Demethylation
Concept	Copper-transporting ATPases
Concept	Oligodendrocyte Precursor Cells
Concept	Circulating Tumor DNA
Concept	CCCTC-Binding Factor
Concept	Poly-ADP-Ribose Binding Proteins
Concept	Optical Imaging
Concept	Mechanistic Target of Rapamycin Complex 2
Concept	Gene Ontology
Concept	Clustered Regularly Interspaced Short Palindromic Repeats
Concept	Carcinogenesis
Concept	Spatial Learning
Grant	Discovering the epigenetics of RNA modifications
Grant	RNA methylation and regulatory T cells
Grant	Interrogation of dynamic RNA modifications in beta cells in type 1 diabetes
Grant	Recognition and mechanism of N6-methyl adenosine modifications
Grant	Global Cysteine Modifications in Human Pathogens
Grant	Predoctoral Training Program in Chemistry and Biology - Renewal 01
Grant	Direct Oxidative Nucleic Acids Demethylation
Grant	Labeling and sequencing of 5hmC and 5mC in DNA-Renewal
Grant	Base-resolution sequencing of m6A in RNA
Grant	Direct Oxidative Nucleic Acids Demethylation
Academic Article	Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation.
Academic Article	Advances in targeting RNA modifications for anticancer therapy.
Academic Article	Genome-Wide Mapping Implicates 5-Hydroxymethylcytosines in Diabetes Mellitus and Alzheimer's Disease.
Academic Article	METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity.
Academic Article	6mA-METL-9 axis regulates innate immunity in C. elegans.
Academic Article	PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines.
Academic Article	PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines.
Academic Article	Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma.
Academic Article	Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research.
Academic Article	Base-resolution quantitative DAMM-seq for mapping RNA methylations in tRNA and mitochondrial polycistronic RNA.
Academic Article	Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA.
Academic Article	Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing.
Academic Article	Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome.
Academic Article	KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions.
Academic Article	5-Hydroxymethylcytosine signals in serum are a predictor of chemoresistance in high-grade serous ovarian cancer.
Academic Article	5-Hydroxymethylcytosine Profiling of Cell-Free DNA Identifies Bivalent Genes That Are Prognostic of Survival in High-Risk Neuroblastoma.

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